G4753
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G4753
Sigma
Griseofulvin
from Penicillium griseofulvum, 97.0-102.0%
| Synonym: | (2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione |
| CAS Number: | 126-07-8 |
| Linear Formula: | C17H17ClO6 |
| Molecular Weight: | 352.77 |
| Beilstein Registry Number: | 95226 |
| EC Number: | 204-767-4 |
| MDL number: | MFCD00082343 |
| PubChem Substance ID: | 24895185 |
Description
| Biochem/physiol Actions | Antifungal. Mode of action: Disrupts the mitotic spindle structure and inhibits nuclear division.1 Induces apoptosis in human tumor cell lines.2 |
Properties
| biological source | from Penicillium griseofulvum |
| assay | 97.0-102.0% |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 60-61-40-43 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | WG9800000 |
References
| Cited Reference | 1. Gull, K. and Trinci, A.P., Griseofulvin inhibits fungal mitosis. Nature 244, 292-4 , (1973) Abstract |
| 2. Panda D., et al., Kinetic suppression of microtubule dynamic instability by griseofulvin: implications for its possible use in the treatment of cancer. Proc. Natl. Acad. Sci. U. S. A. 102, 9878-83, (2005) Abstract | |
| Merck | Merck 13,4564 |
| Beilstein | Beil. 18,V,5,150 |
